Cystic fibrosis

We are assessing how effective antibiotics are at reducing lung infections in patients with cystic fibrosis (CF), and the psychological impact of the condition on patients and their caregivers.

Key investigator: Dr Mary Carroll

Progress to date

  • In collaboration with Kings College London, we have been instrumental in describing the airway microbiome, identifying the bacteria typically found in the lungs of cystic fibrosis patients. 
  • Multiple commercial clinical trials have been completed, most notably two small molecule disease-modifyiers in a genetic subset of CF patients.
  • Our Scottie study, funded by the Anna Trust, aims to optimise antibiotic therapy during lung infection by detailing bacterial changes in CF patients’ lungs before, during and after infections that exacerbate their condition.
  • We are also assessing the psychological impact of the condition, including the prevalence of depression and anxiety, on CF patients and their caregivers. 

University links