Synbiotic supplements in Non-Alcoholic Fatty Liver Disease - INSYTE study

The INSYTE study is assessing the effects of a synbiotic supplement on non alcoholic fatty liver disease (NAFLD), condition that sees fat build up in the liver causing inflammation and loss of function.

Jump to taking part in NAFLD studies here.

Tackling a serious condition

Affecting an estimated one in five people in the UK, NAFLD involves excess fat develop in the liver and if left unmanaged will lead to scarring (cirrhosis) and ultimately liver failure. There are limited options available for effective treatment and management of this condition.

The NIHR Southampton Biomedical Research Centre’s WELCOME study established that the Omacor supplement, a highly purified omega-3 fatty acid, reduced liver fat whilst increasing levels of beneficial omega-3 fat in other tissue of the body for most participants.

Led by centre investigator Professor Christopher Byrne, the WELCOME study involved 100 volunteers with NAFLD recruited from centres across the South of England, with participants were given a comprehensive body assessment through a range of tests related to the liver, body composition, diabetes and cardiovascular disease.

From fatty acids to healthy bacteria

In the latest study, INSYTE, Professor Byrne’s team will test the effects of a daily synbiotic supplement, containing a mixture of healthy bacteria (probiotic) and a sugar that is not broken down and absorbed into the blood (prebiotic), on the health and liver fat levels amongst those with NAFLD.

The balance of healthy and harmful bacteria in our intestines is key to normal digestion, excessive harmful bacteria could cause problems leading to excess fat build up in the liver. The INSYTE study will assess whether bolstering the healthy bacteria population reduces these effects.

Taking part in NAFLD studies

You can view full INSYTE  trial and participation information on the UK Clinical Research Network Study Portfolio here

Or you discuss participation in our NAFLD studies directly with the team using the contact details below.

Ms Lucinda England

  • Tel: 44 0 23 8079 5006
  • L.C.England@southampton.ac.uk