Byrne, Professor Christopher David

MB BCh (Wales)
FRCP (UK), FRCPath (UK),
PhD (Cantab)
Head Academic Unit of Endocrinology & Metabolism

Speciality

Endocrinology & Metabolism

Sub-speciality

Lipids (including diagnostic lipids in Chemical Pathology) and Obesity

Training and Education

University of Wales College of Medicine, Cardiff 1978-83
Downing College, Cambridge 1989-92
Stanford University, Stanford CA, USA 1992-94

Experience

Professor Byrne has worked for Southampton University Hospitals Trust since 1999.

Trained in Cardiff, Hammersmith and Cambridge hospitals, in Medicine, Endocrinology and Chemical Pathology.
Medical Research Council Clinical Fellow, Cambridge University
Post doctoral research fellow, Stanford University, California

Clinical scientist undertaking original research related to metabolic syndrome and obesity; relevant to metabolism, vascular disease and liver disease.

Honorary Consultant Physician and Medical Research Council Fellow, Addenbrooke’s Hospital Cambridge 1996-1999

Key achievements

Inaugural Director of Southampton University Hospitals Trust Wellcome Trust Clinical Research Facility.

Royal Society of Medicine (& Committee member Lipids & Cardiovascular Risk
section).
Hon Junior Secretary. Research Grants Committee member Diabetes UK

Co-applicant National Institute for Health Research
Southampton Biomedical Research Unit in  Nutrition, Diet & Lifestyle (Obesity)

Member of:
DOHaD Society
British Diabetic Association
European Association for the Study of Diabetes
British Atherosclerosis Society

Key awards and prizesGlaxo Research Fellow   1989       

MRC Training Fellow                         1990-92   
Pfizer Academic Travel Award            1991
Peel Trust Travelling Fellow                1992-93
Cambridge University/Parke Davis 
Travelling Fellow                                1993-94
MRC Fellow                                      1994-99
Fournier Lipidology Award                  1999
British Hyperlipidaemia Association
& Parke Davis/Pfizer Award                1999
John French Lectureship                    1999
Eli Lilly Award                                   2000
Membership
Association of Physicians member     2003
ACCEA National Bronze award          2008

Research

Clough GF, L'Esperance V, Turzyniecka M, Walter L, Chipperfield AJ, Gamble J, Krentz AJ, Byrne CD. Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity but is not improved by high dose statin treatment. Microcirculation. 2010. In press.

Ahmed MH, Byrne CD. World J Gastroenterol. Obstructive sleep apnea syndrome and fatty liver: Association or causal link? 2010 Sep 14;16(34):4243-52.

Hyde MJ, Clarke L, Griffin JL, Herrera E, Byrne CD, Kemp PR. A single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal piglets. Metabolomics. 2010. In press.

Ahmed MH & C. D. Byrne CD. Potential therapeutic uses for ezetimibe beyond lowering LDL-c to decrease cardiovascular events. Diabetes, Obesity and Metabolism. 2010 Nov;12(11):958-66. PMID: 20880342.

Ahmed MH, Byrne CD. Ezetimibe as a potential treatment for non alcoholic fatty liver disease: is the intestine a modulator of hepatic insulin sensitivity and hepatic fat accumulation? Drug Discovery Today. 2010 Aug;15(15-16):590-5. Epub 2010 Jun 18. PMID: 20601094.

Ahmed MH and Byrne CD. Bariatric surgery and renal function: a precarious balance between benefit and harm. Nephrology Dialysis Transplantation. 2010 Oct;25(10):3142-7. Epub 2010 Jun 21. PMID: 20566568.

Turzyniecka M, Wild SH, Krentz AJ, Chipperfield AJ, Clough GF, Byrne CD. Diastolic function is strongly and independently associated with cardio-respiratory fitness in central obesity. J Appl Physiol. 2010 Jun;108(6):1568-74. Epub 2010 Mar 25.PMID: 20339006.

Ahmed MH, Olufadi R, Byrne CD. Clinical Publishing. The Year in Lipid Disorders; Volume 2. ed PP Toth. Metabolic syndrome, diabetes and cardiovascular risk. PP 24-45. Oxford. 2010.

Byrne CD, Wild SH. Body fat and increased risk of cirrhosis. Better diagnosis and treatment of non-alcoholic fatty liver disease are needed. BMJ 2010 Mar 11; 340:c774. PMID: 20223874.

Rana O, Byrne CD, Greaves K. Intensive Insulin Therapy in the Intensive Care Unit, Hypoglycemia and Cardiovascular Mortality. Hospital Practice 2010; 38 (2): 59-66.

Byrne CD Fatty liver: Role of inflammation and fatty acid nutrition. Prostaglandins, Leukotrienes and Essential Fatty Acids 2010 82: 265–271. PMID: 20189787.

Ahmed MH, Abu EO, Byrne CD. Non Alcoholic Fatty Liver Disease (NAFLD): New challenge for general practitioners and important burden for health authorities? Primary Care Diabetes 2010 Oct;4(3):129-37. Epub 2010 Mar 17. PMID: 20299294.

Clough GF, Avery MR, Voegeli D, Byrne CD, Simpson DM. Cutaneous vascular response to local warming. Microcirculation 2010 17: 81-82.

Byrne CD. Hypoxia and non alcoholic fatty liver disease. Clin Sci (Lond). 2010 118; 397-400. PMID: 19900166.

Bruce KD, Byrne CD. Royal College of Physicians. Horizons in Medicine volume 21. ed J S Friedland. Metabolic Syndrome pp 39-46. London: RCP; 2009.

Oluwatowoju I, Abu E, Wild SH, Byrne CD. Improvements in glycaemic control and cholesterol concentrations associated with the Quality and Outcomes Framework: a regional 2 year audit of diabetes care in the UK. Diabetic Medicine 2010 27: 354-360.

Olufadi R, Wild SH, Byrne, CD (December 2009) Cholesterol Metabolism and Vascular Disease. In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0002264.pub2].

Valletta JJ, Chipperfield AJ, Byrne CD. Gaussian process modelling of blood glucose response to free-living physical activity data in people with type 1 diabetes. Conf Proc IEEE Eng Med Biol Soc. 2009;1:4913-6.

Avery MR, Voegeli D, Byrne CD, Simpson DM, Clough GF. Age and Cigarette Smoking are Independently Associated with the Cutaneous Vascular Response to Local Warming', Microcirculation. 2009 Nov;16(8):725-34.

Bruce KD, Cagampang FR, Argenton M, Zhang J, Ethirajan PL, Burdge GC, Bateman AC, Clough GF, Poston L, Hanson MA, McConnell JM, Byrne CD. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology. 2009 Dec;50(6):1796-1808. PMID: 19816994.

Zhang J, Zhang F, Didelot X, Bruce KD, Cagampang F, Vatish M, Hanson M, Lehnert H, Ceriello A, Byrne CD. Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics 2009 Oct 16;10(1):478. PMID: 19835573.

Bruce KD, Byrne CD. The Metabolic Syndrome: Common Origins of a Multi-Factorial Disorder. Postgraduate Med J. 2009 Nov;85(1009):614-21.

Turzyniecka M, Wild SH, Krentz AJ, Chipperfield AJ, Gamble J, Clough GF, Byrne CD. Skeletal muscle microvascular exchange capacity is associated with hyperglycaemia in subjects with central obesity. Diabet. Med. 2009 26, 1112–1119.