Crabb, Dr Simon

BSc, MBBS, MRCP, PhD

Speciality

Medical Oncology

Sub-speciality

Genitourinary cancer (bladder, prostate and kidney cancers)

Training and Education

Dr Crabb trained at St George's Hospital Medical School, London. After junior doctor posts at various London teaching hospitals he trained in the care of patients with cancer in Southampton.  During this time he undertook doctoral research as a Cancer Research UK Clinical Research Fellow at the University of Southampton and a Clinical Research Fellowship in Medical Oncology at the British Columbia Cancer Agency in Vancouver. Finally he returned as a Clinical Lecturer in Medical Oncology to the University of Southampton

Experience

Dr Crabb has worked for Southampton University Hospitals Trust since October 2009. 

Dr Crabb specialises in the care of patients with cancers of the genitourinary tract including kidney, bladder and prostate cancers. He has particular interests in developing and participating in clinical trials of new treatments for these diseases.

Key achievements

Dr Crabb has undertaken a number of clinical and laboratory research projects aimed at developing new and hopefully better treatments for cancer. This program of research currently includes work into treatments to target epigenetic mechanisms in cancer and is focused on bladder and prostate cancers (described in detail on the University of Southampton website).

Key awards and prizes

Pollock Prize
Novartis Canadian Young Investigator Award, 2007

Research

Crabb SJ, Patsios D, Sauerbrei E, Ellis PM, Arnold A, Goss G, Leighl NB, Shepherd FA, Powers J, Seymour L, et al: Tumor cavitation: impact on objective response evaluation in trials of angiogenesis inhibitors in non-small-cell lung cancer. J Clin Oncol 2009, 27(3):404-10

Crabb SJ, Howell M, Rogers H, Ishfaq M, Yurek-George A, Carey K, Pickering BM, East P, Mitter R, Maeda S, et al: Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A. Biochem Pharmacol 2008, 76:463-75

Crabb SJ, Hague A, Johnson PW, Packham G: BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. Oncol Rep 2008, 19:689-96

Crabb SJ, Bajdik CD, Leung S, Speers CH, Kennecke H, Huntsman DG, Gelmon KA: Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study. Breast Cancer Res 2008, 10:R6

Crabb SJ, Cheang MCU, Leung S, Immonen T, Nielsen TO, Huntsman DD, Bajdik CD, Chia SK: The basal breast cancer molecular subtype predicts for a lower incidence of axillary lymph node metastases in primary breast cancer. Clin Breast Cancer 2008, 8:249-56

Crabb SJ, McKendrick JJ, Mead GM: Brain as sanctuary site of relapse in germ cell cancer patients previously treated with chemotherapy. Clin Oncol 2002, 14:287-93