Holt, Professor Richard

MA MB BChir PhD FRCP FHEA

Speciality

Diabetes

Sub-speciality

Diabetes and pregnancy, young adult diabetes, Cystic Fibrosis related diabetes

Training and Education

1983-1986 St Catharine's College, Cambridge University MA, MB BChir
1986-1989 The London Hospital Medical College
1992 The Royal College of Physician MRCP
1994-1998 King's College School of Medicine & Dentistry PhD
2006 The Royal College of Physician FRCP
2007 Higher Education Academy FHEA

Experience

Professor Holt has worked for Southampton University Hospitals Trust since May 2000.

Professor Holt undertook his pre-clinical training at St Catharine’s College, University of Cambridge and clinical training at the London Hospital Medical College.

Professor Holt completed his specialist training in Diabetes and Endocrinology in the South East Thames Region. During this time, Professor Holt was awarded a PhD while working as a MRC Clinical Training Fellow at King’s College Hospital.

Key achievements

Clinical: Professor Holt leads the diabetes clinics for pregnancy, young adults and people with cystic fibrosis. The pregnancy clinic has undertaken innovative research which has informed both local and NICE national guidelines.

Research: Professor Holt’s research funding exceeds £3m. He is an international expert in the links between diabetes and mental illness. In addition he is an expert in doping with growth hormone and acts as an adviser to UK Sport (including 2012 preparations) and World and US Anti-Doping Agencies. He has lectured nationally and internationally on these subjects. He has published nearly 100 articles in peer reviewed journals is the editor of a new Textbook of Diabetes. He is deputy editor of Diabetic Medicine and Reviews Editor for Diabetes Obesity and Metabolism.

Teaching: Professor Holt is involved in both postgraduate and undergraduate teaching in Southampton. He is a fellow of the Higher Education Academy

Other: Professor Holt chairs the Diabetes UK Council of Healthcare Professionals and work closely with NHS Diabetes, Royal College of Physicians and NICE to implement the National Service Framework for Diabetes. Professor Holt has contributed to Diabetes UK guidelines and position statements. He was an author of the Joint European Societies guidelines on the management of diabetes and cardiovascular risk in severe mental illness. He was a member of the NICE diabetes and pregnancy guideline development group and currently represents Diabetes UK on the NICE diabetes prevention programme development group.

Key awards and prizes

1994-98: MRC Clinical Training Fellow
1995, 1998 European Society of Paediatric Gastroenterology and Nutrition Travel Award
1996 Society for Endocrinology and Royal Society Travel Award
1997 European Society of Paediatric Gastroenterology and Nutrition Young Investigator's Award
1998, 2000 Society for Endocrinology Travel Award
2004 HM Queen’s recognition of services to Health and Life Sciences
2011: Diabetes UK Mary Mackinnon Lectureship

Research

Holt RIG, Goddard JR, Clarke P, Coleman MAG. (2003) A postnatal fasting plasma glucose is useful in determining which women with gestational diabetes should undergo a postnatal oral glucose tolerance test. Diabetic Medicine 20(7):594-8

Holt RIG, Clarke P, Parry EC, Coleman MA. (2008) The effectiveness of glibenclamide in women with gestational diabetes. Diabetes Obes Metab 10(10):906-11.

Citrome L, Holt RIG, Zachry WM, Clewell JD, Orth PA, Karagianis JL, Poole Hoffman V. (2007) Risk of treatment-emergent diabetes mellitus in patients receiving antipsychotics. Annals of Pharmacotherapy; 41: 1593-603

Smith M, Hopkins D, Peveler RC, Holt RI, Woodward M, Ismail K. First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: systematic review and meta-analysis. Br J Psychiatry. 2008;192(6):406-11

Holt RI, Pendlebury J, Wildgust HJ, Bushe CJ; Intentional weight loss in overweight and obese patients with severe mental illness: 8-year experience of a behavioral treatment program. J Clin Psychiatry. 2010;71(6):800-5

Winocour PH, Gosden C, Walton C, Nagi D, Turner B, Williams R, James J, Holt RIG. Association of British Clinical Diabetologists (ABCD) and Diabetes-UK survey of specialist diabetes services in the UK, 2006. 1. The consultant physician perspective. Diabet Med. Jun;25(6):643-50.

Erotokritou-Mulligan I, Bassett EE, Bartlett C, Cowan D, McHugh C, Seah R, Curtis B, Wells V, Harrison K, Sönksen PH, Holt RIG; GH-2004 Group. (2008) The effect of sports injury on insulin-like growth factor-I and type 3 procollagen: implications for detection of growth hormone abuse in athletes. J Clin Endocrinol Metab. Jul;93(7):2760-3. Epub 2008 Apr 15

Erotokritou-Mulligan I, Eryl Bassett E, Cowan DA, Bartlett C, Milward P, Sartorio A, Sönksen PH, Holt RI The use of growth hormone (GH)-dependent markers in the detection of GH abuse in sport: Physiological intra-individual variation of IGF-I, type 3 pro-collagen (P-III-P) and the GH-2000 detection score. Clin Endocrinol (Oxf). 2010;72(4):520-6

Guha N, Erotokritou-Mulligan I, Burford C, Strobridge G, Brigg J, Drake T, Bassett EE, Cowan D, Bartlett C, Sönksen PH, Holt RI. Serum insulin-like growth factor-I and pro-collagen type III N-terminal peptide in adolescent elite athletes: implications for the detection of growth hormone abuse in sport. J Clin Endocrinol Metab. 2010;95(6):2969-76

Holt RI, Erotokritou-Mulligan I, McHugh C, Bassett EE, Bartlett C, Fityan A, Bacon JL, Cowan DA, Sönksen PH The GH-2004 project: the response of IGF1 and type III pro-collagen to the administration of exogenous GH in non-Caucasian amateur athletes. Eur J Endocrinol. 2010l;163(1):45-54.

Holt RIG, Sönksen PH. (2008) Growth hormone, IGF-I and insulin and their abuse in sport. Br J Pharmacol. Jun;154(3):542-56. Review.

Holt RI, Peveler RC Obesity, serious mental illness and antipsychotic drugs. Diabetes Obes Metab. 2009 Jul;11(7):665-79.

Guideline Development Group Management of diabetes from preconception to the postnatal period: summary of NICE guidance. BMJ. 2008 Mar 29;336(7646):714-7.

De Hert M, Dekker JM, Wood D, Kahl KG, Holt RI, Möller HJ Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry. 2009 Sep;24(6):412-24. Epub 2009 Aug 13

Textbook of Diabetes 4th Edition. Edited by Holt RI, Cockcram CS, Flyvbjerg A, Goldstein BJ. Wiley Blackwell Chichester 2010.