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Lotery, Professor Andrew
Lotery, Dr Helen
Lovett, Dr Joanna
Lucas, Dr Jane
Lucassen, Dr Anneke
Lukman, Dr Henny

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Lotery, Professor Andrew

MD, FRCOphth Andrew Lotery

Speciality

Ophthalmology

Sub-speciality

Medical retinal

Training and Education

Queen's University Belfast, University of Iowa

Experience

Professor Lotery has worked for Southampton University Hospitals Trust since September 2002.

I specialise in looking after patients with inherited retinal diseases, diabetic retinopathy and age related macular degeneration. My clinical interests are in medical retinal diseases such as age related macular degeneration, diabetic retinopathy and inherited retinal diseases. I also teach and perform cataract surgery.

Key achievements

I have identified several genetic risk factors for eye diseases, particularly age related macular degeneration. I have led the development of the medical retinal service at Southampton Eye Unit over the last seven years.

Key awards and prizes

Senior Investigator National Institute of Health Research, Clinical advisor to NICE, Editor in chief of Eye, Member MRC College of Experts, Member of Royal College of Ophthalmology Scientific and Examination Committees. Nettleship medal of the Royal College of Ophthalmology, Richard Havelock Charles Scholarship and Gold Medal, Queen’s University, Belfast.

Research

My research interests include clinical trials of new treatments for diseases such as macular degeneration. I also lead a research team which studies the genetics of eye diseases and is working to develop new therapies for eye diseases with stem cells.

Find out more about Professor Lotery's vision research at the University of Southampton|.

Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, Jones S, Collins A, Stone E, Lotery A. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. Lancet 2008;372:1828-34.

Goverdhan SV , Khakoo SI , Gaston H, Chen X, Lotery AJ . Age-related macular degeneration is associated with the HLA - Cw *0701 Genotype and the natural killer cell receptor AA haplotype. Invest Ophthalmol Vis.Sci. 2008;49:5077-82.

Goverdhan SV , Ennis S, Hannan SR , Madhusudhana KC, Cree AJ , Luff AJ , Lotery AJ . Interleukin-8 promoter polymorphism - 251A /T is a risk factor for age-related macular degeneration. Br J Ophthalmol 2008;92:537-40.

Goverdhan SV , Hannan S, Newsom RB , Luff AJ , Griffiths H, Lotery AJ . An analysis of the CFH Y402H genotype in AMD patients and controls from the UK, and response to PDT treatment. Eye 2008;22:849-54.

Raftery J, Clegg A, Jones J, Tan SC, Lotery A. Ranibizumab ( Lucentis ) versus bevacizumab ( Avastin ): modelling cost effectiveness. Br J Ophthalmol 2007;91:1244-6.

Raftery JP , Lotery A. The cheaper drug, bevacizumab , should be referred to NICE. BMJ 2007;334:381-2.

Ennis S, Goverdhan S, Cree A, Hoh J, Collins A, Lotery A. Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region. Br J Ophthalmol 2007;91:966-70.

Lotery AJ , Baas D, Ridley C, Jones RP , Klaver CC, Stone E, Nakamura T, Luff A, Griffiths H, Wang T, Bergen AA, Trump D. Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa . Hum. Mutat . 2006;27:568-74.

Goverdhan SV , Howell MW , Mullins RF , Osmond C, Hodgkins PR, Self J, Avery K, Lotery AJ . Association of HLA class I and class II polymorphisms with age-related macular degeneration. Invest Ophthalmol Vis.Sci. 2005;46:1726-34.

Stone EM, Braun TA, Russell SR , Kuehn MH , Lotery AJ , Moore PA, Eastman CG , Casavant TL , Sheffield VC. Missense variations in the fibulin 5 gene and age-related macular degeneration. N. Engl .J Med. 2004;351:346-53.

Lotery AJ , Jacobson SG , Fishman GA, Weleber RG , Fulton AB , Namperumalsamy P, Heon E, Levin AV , Grover S, Rosenow JR, Kopp KK , Sheffield VC, Stone EM. Mutations in the CRB1 gene cause Leber congenital amaurosis. Arch. Ophthalmol 2001;119:415-20.

Stone EM, Lotery AJ , Munier FL, Heon E, Piguet B, Guymer RH, Vandenburgh K, Cousin P, Nishimura D, Swiderski RE, Silvestri G, Mackey DA, Hageman GS , Bird AC, Sheffield VC, Schorderet DF . A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat .Genet. 1999;22:199-202.

Stone EM, Webster AR, Vandenburgh K, Streb LM , Hockey RR, Lotery AJ , Sheffield VC. Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration. Nat .Genet. 1998;20:328-9.

Lotery AJ , Ennis KT , Silvestri G, Nicholl S, McGibbon D, Collins AD, Hughes AE . Localisation of a gene for central areolar choroidal dystrophy to chromosome 17p . Hum. Mol .Genet. 1996;5:705-8.