Neurosurgery

Key areas of research:

  • brain repair from endogenous stem cells
  • advanced intraoperative imaging of brain tumours and eloquent cortex
  • mechanisms and treatment of cognitive impairment after brain injury             
  • seizure prediction.

Book Chapters

1. Gray WP and Bulstrode H. Epilepsy and Glioma. In 'The causes of epilepsy' (2009) Eds Shorvon, Guerrini and Andermann; Cambridge University Press

2. Scharfman HE, Gray WP. Plasticity of neuropeptideY in the dentate gyrus after seizures, and it’s relevance to seizure-induced neurogenesis. In Feuerstein/Zukowska (eds.): NPY Family of peptides in inflammation, immune disorders, angiogenesis  and cancer. (2005) Birkhaeuser Publishing Ltd. Basel, Switzerland.

3. Gray WP, Scharfman HE. NPY and Hippocampal neurogenesis. In Feuerstein/Zukowska (eds.): NPY Family of peptides in inflammation, immune disorders, angiogenesis  and cancer. (2005) Birkhaeuser Publishing Ltd. Basel, Switzerland.

4. Gray WP. Inflamation and neurogenesis. In Malva JO, Rego AC, Cunha RA and Oliveira CR (eds): Interaction between neurons and glia in aging and disease. (2006) Springer.

Selected Papers in refereed journals

Rodrigo, C., Zaben, M., Lawrence, T., Laskowski, A., Howell, O. W. and Gray, W. P. (2010) NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor. J Neurochem. In press.

Barkas, L. J., Henderson, J. L., Hamilton, D. A., Redhead, E. S. and Gray, W. P. (2010) Selective temporal resections and spatial memory impairment: Cue dependent lateralization effects. Behavioural brain research. In press.

Zaben M, Sheward, W., Shtaya, A., Abbosh, C., Harmar, A., Pringle, A., Gray, WP. The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC(2) receptors, or directs them towards a neuronal fate via VPAC(1) receptors. Stem Cells, 27, 2539-2551.

Watkins, A.J., Wilkins, A., Cunningham, C., Perry, V.H., Seet, M.J., Osmond, C., Eckert, J.J., Torrens, C., Cagampang, F.R., Cleal, J., Gray, W.P., Hanson, M.A. & Fleming, T.P. (2008) Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. The Journal of physiology, 586, 2231-2244.

Gray, W.P. (2008) Neuropeptide Y signalling on hippocampal stem cells in health and disease. Molecular and cellular endocrinology; 288, 52-62.

Scharfman, H.E. and Gray, W.P. (2007) Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Epilepsia, 48 Suppl 2, 33-41.

Laskowski, A., Howell, O.W., Sosunov, A.A., McKhann, G. and Gray, W.P. (2007) NPY mediates basal and seizure-induced proliferation in the subcallosal zone. Neuroreport, 18, 1005-1008.

Howell, O.W., Silva, S., Scharfman, H.E., Sosunov, A.A., Zaben, M., Shatya, A., McKhann, G., 2nd, Herzog, H., Laskowski, A. and Gray, W.P. (2007) Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiology of disease, 26, 174-188.

Scharfman, H.E. and Gray, W.P. (2006) Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis. Exs, 193-211.

Sadgrove, M.P., Laskowski, A. and Gray, W.P. (2006) Examination of granule layer cell count, cell density, and single-pulse BrdU incorporation in rat organotypic hippocampal slice cultures with respect to culture medium, septotemporal position, and time in vitro. J Comp Neurol, 497, 397-415.

Walker, M., Cross, H., Smith, S., Young, C., Aicardi, J., Appleton, R., Aylett, S., Besag, F., Cock, H., Delorenzo, R., Drislane, F., Duncan, J., Ferrie, C., Fujikawa, D., Gray, W., Kaplan, P., Koutroumanidis, M., O'Regan, M., Plouin, P., Sander, J., Scott, R., Shorvon, S., Treiman, D., Wasterlain, C. and Wieshmann, U. (2005) Nonconvulsive status epilepticus: Epilepsy Research Foundation Workshop Reports. Epileptic Disord, 7, 253-296.

Vajramani, G.V., Jones, G., Bayston, R. and Gray, W.P. (2005) Persistent and intractable ventriculitis due to retained ventricular catheters. Br J Neurosurg, 19, 496-501.
Sadgrove, M.P., Chad, J.E. and Gray, W.P. (2005) Kainic acid induces rapid cell death followed by transiently reduced cell proliferation in the immature granule cell layer of rat organotypic hippocampal slice cultures. Brain Res, 1035, 111-119.

Howell, O.W., Doyle, K., Goodman, J.H., Scharfman, H.E., Herzog, H., Pringle, A., Beck-Sickinger, A.G. and Gray, W.P. (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem, 93, 560-570.

Huttmann, K., Sadgrove, M., Wallraff, A., Hinterkeuser, S., Kirchhoff, F., Steinhauser, C. and Gray, W.P. (2003) Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur J Neurosci, 18, 2769-2778.

Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. & Gray, W.P. (2003) Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem, 86, 646-659.

Gray, W.P., May, K. and Sundstrom, L.E. (2002) Seizure induced dentate neurogenesis does not diminish with age in rats. Neurosci Lett, 330, 235-238.

Gray, W.P. and Sundstrom, L.E. (1998) Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res, 790, 52-59.