University Hospital Southampton NHS Foundation Trust

CHIP - the Control of Hyperglycaemia in Paediatric Intensive Care

There is some controversial data from adult studies, some of which suggests that the tight control of blood sugar in critically ill patients (mainly surgical) confers significant benefit in terms of reductions in length of ICU stay, rate of infections and the need for renal replacement therapy etc. Before creeping acceptance of this approach took hold in PICU, Duncan Macrae (Director of PICU at the Royal Brompton) and the Paediatric Intensive care Study Group designed a study to investigate the effects of tight versus normal glycaemic control in children on PICU. Only high risk children (ventilated and receiving treatment with vasoactive were targeted as this group is known to have a mortality of about 20%). The study is funded by a 1 million pound grant from the Health Technology Assessment agency. We started recruiting just over a year ago and in total have recruited 478 patients out of a target of 1500. Southampton is the UK’s second highest recruiter (70 children).

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