Prof Mike Grocott, research lead for lung injury and critical care

Mike Grocott

Critical care consultant and researcher with a focus on hypoxia, lung injury and perioperative care, Mike Grocott leads the critical care research area within the NIHR Southampton Biomedical Research Centre.


Enabling Southampton's respiratory research

As lead for critical care within the NIHR BRC, he is leading efforts to address key unmet needs in critical illness across the life-course, including hypoxia (Xtreme Everest programme), lung injury, resuscitation, rehabilitation after critical illness, and perioperative care (including the Fit-4-Surgery programme).

Focus on hypoxia, lung injury and perioperative care

Professor Grocott’s personal research focus is on:

  • Understanding inter-individual differences in hypoxia tolerance in order to develop novel therapies and diagnostics for critically ill patients and other suffering with low oxygen levels (Xtreme Everest programme)
  • Exploring the relationship between physical fitness, physical exercise and outcome following surgery and developing novel interventions to minimise the harm of medical interventions including surgery and chemotherapy (Fit-4-Surgery programme)
  • Lung injury and the role of the lung in driving systemic manifestations of critical illness

Integrative human physiology

Professor Grocott's own research has focussed on integrative human physiology in health volunteers to drive a programme of translational research in patients.  Specifically, he has focussed on identifying novel interventions and biomarkers in the area of hypoxia tolerance and on the relationship between physical fitness, exercise and outcome in the preoperative period. His approach has been to use high-quality physiological phenotyping in large groups of healthy volunteers linked to modern ‘omics approaches to explore inter-individual differences and thereby identify mechanisms of good and bad adaptation.

Extensive collaborations

Professor Grocott collaborates widely nationally and internationally.  He leads the Xtreme Everest Oxygen Research Consortium, an international collaboration led by UCL and the University of Southampton along with Duke University Medical Centre (US) and including the universities of Cambridge, Oxford, Amsterdam, Milan, Seattle, and Bern.

He also leads the Fit-4-Surgery research collaboration with collaborators in Liverpool, Kings, UCL and South Tees.


Professor Grocott trained in medicine and immunology at St George’s Hospital Medical School, University of London, and completed his research training within the Centre for Anaesthesia, UCL.  He completed general professional training in internal medicine and UK anaesthesia fellowship training and now practices as a critical care physician.

Whilst at UCL, he established the Centre for Altitude Space and Extreme Environment Medicine and the Surgical Outcomes Research Centre. He went on to establish the NIAA Health Services Research Centre at the Royal College of Anaesthetists.