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Carboplatin (AUC7)

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Chemotherapy Protocol GERM CELL CARBOPLATIN (AUC 7) Regimen • Germ Cell – Carboplatin (AUC7) Indication • Stage I seminoma of the testis with no
Url
/Media/UHS-website-2019/Docs/Chemotherapy-SOPs1/Germcell/Carboplatin-AUC7.pdf

Preventing infection - patient information

Description
Preventing infection Information for patients 3 At University Hospital Southampton NHS Foundation Trust (UHSFT)
Url
/Media/UHS-website-2019/Patientinformation/Visitinghospital/Preventinginfection-patientinformation.pdf

During your stay in hospital: COVID-ZERO - patient information

Description
Information about preventing the spread of COVID-19 during your stay in hospital.
Url
/Media/UHS-website-2019/Patientinformation/COVID-19/During-your-stay-in-hospital-COVID-ZERO-2858-PIL.pdf

Macmillan urology cancer clinical nurse specialist team - patient information

Description
During your treatment for cancer, our urology cancer clinical nurse specialists will be responsible for coordinating your care.
Url
/Media/UHS-website-2019/Patientinformation/Cancercare/Macmillan-urology-cancer-clinical-nurse-specialist-team-3711-PIL.pdf

Southampton PTC - Approved chemotherapy regimens 9 June 2020

Description
Appendix B: SOUTHAMPTON PAEDIATRIC ONCOLOGY PRINCIPAL TREATMENT CENTRE List of Approved Chemotherapy Regimens Updated 9th June 2020 Review Date: June 2021 Agreements 1 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Position Head Of Chemotherapy Service Name Dr Juliet Gray Organisation UHS Date agreed 19/2/2019 Disease / Indication LEUKAEMIA Acute lymphoblastic leukaemia: First line therapy Paediatric Chemotherapy Group Regimen / protocol Approved chemotherapy regimens Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG As per UKALL 2011 Oral / IV bolus, IV infusion/ IM / s.c./ intrathecal Oral 6MP / MTX I V vincristine IV/s.c bolus Cytarabine IM asparaginase IV Daunorubicin and Doxorubicin (Level 2 only) IV/s.c bolus Cytarabine Oral 6MP / MTX 2 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Relapse / 2nd line therapy Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG As per UKALL R3 Interim Oral / IV bolus, IV Oral 6MP / MTX / TG IV/s.c Cytarabine guidance infusion / IM/ s.c./ IV vincristine Oral 6MP / MTX /6TG intrathecal IV/s.c Cytarabine IM asparaginase Blinatumomab Iv infusion Nlearabine as per CCLG IV infusion UKALL 2019 interim guidelines Philadelphia positive Infants Acute Myeloid Leukaemia First line therapy Relapse / 2nd line therapy Interim recommendations for Ph +ve children, June 2014 As per Interfant 2006 : CCLG Guidelines 2016 Myechild 01 UK Guidelines for relapsed AML (2010) Azacitidine NICE TA218 Oral / IV bolus, IV infusion / IM/ s.c./ intrathecal Oral / IV bolus, IV infusion / IM/ s.c./ intrathecal IV Infusion / IV bolus/ intrathecal IV Infusion / IV bolus/ intrathecal IV infusion SC bolus Oral 6MP / MTX /imatinib IV vincristine IV/s.c Cytarabine IM asparaginase Oral 6MP / MTX/6TG IV vincristine IV/s.c Cytarabine IM asparaginase IV/s.c Cytarabine Oral 6MP / MTX /imatinib / 6TG IV/s.c: Cytarabine Oral 6MP / MTX /6TG In children with Downs Syndrome CCLG guidelines (March IV infusion/ IV bolus 2014) 3 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication APML Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Guidelines for standard risk IV infusion/ IV bolus / children with APL (SR-ICC oral APL Study 02) Oral ATRA Chronic Myeloid Leukaemia Leukaemia Working Group Oral / iv bolus / iv Oral hydroxyurea Oral hyroxyurea / imatinib guidelines infusion /imatinib APLASTIC ANAEMIA CCLG recommendations for the management of CML in children and young people up to the age of 18years (Dec 2014) BSH Diagnosis and Management of Aplastic Anaemia, updated 2017 Iv infusion LYMPHOMA T cell and pre-B Lymphoma Burkitts / Large B cell lymphoma Initial therapy As per UKALL 2011 Oral / IV bolus, IV IV vincristine infusion/ IM / s.c./ IV /s.c. cytarabine intrathecal Oral 6MP/MTX As per Inter-B-NHL Ritux IV infusion / iv bolus / 2010 oral / intrathecal Oral 6MP / MTX IV /s.c cytarabine Relapse / second line therapy CCLG B-cell guidelines 2003 R-ICE NHL IV infusion / iv bolus / oral / intrathecal 4 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Anaplastic large cell lymphoma Initial therapy Relapse CCLG guidelines (June 2009) As per ALCL relapse NHL 2006 01 IV infusion/ iv bolus / oral / intrathecal IV infusion/ iv bolus / oral / intrathecal IV Vinblastine Primary Mediastinal B cell Dose-adjusted R-EPOCH IV infusion/ iv bolus / Lymphoma oral / intrathecal Inter-B-NHL Ritux 2010 Hodgkin’s (classical) First line therapy CCLG interim (July 2013) guidelines Oral / IV bolus / IV infusion IV vincristine Oral prednisolone IV Cyclophosphamide (Level 2 only) Oral prednisolone Relapse / second line therapy EURONET PHL C2 trial As per guidelines EuroNet-PH1: ABVD IEP BEAM within Oral / IV bolus / IV infusion Iv bolus / infusion / oral IV vincristine Oral prednisolone IV Cyclophosphamide (Level 2 only) IV doxorubicin (Level 2 only) IV Vinblastine Oral prednisolone 5 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Hodgkin’s (lymphocyte predominant) As per Euronet LP-1 study Iv bolus / infusion /oral iv vinblastine, Oral prednisolone oral prednisolone SOLID TUMOURS Ewings sarcoma Initial therapy As per Euro Ewings 2012 Iv bolus / iv infusion Or CCLG Flow sheet Oct 2019 Relapse / second line therapies As per CCLG flowsheet Iv infusion / oral (Aug 2017) rEECur: Oral temozolomide Oral temozolomide IV irinotecan (level 2 only) Irinotecan / temozolomide rEECur Germ Cell Tumours Initial therapy Relapsed disease TreoMel CCLG Interim guidelines for the treatment of germ cell tumours in children and adolescents (Jun 2018) Guidelines within GC III Iv infusion / bolus Iv infusion / bolus 6 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication HLH Hepatoblastoma Initial therapy (standard risk) Initial therapy (high risk) Hepatocellular carcinoma Langerhans Cell Histiocytosis Initial disease Refractory disease Nasopharyngeal carcinoma Regimen / protocol As per HLH 2004 Routes of Drugs that can be Drugs that can to be Approved by administration given in POSCU given in Community SPCG IV bolus / infusion CCLG Treatment Iv infusion guidelines for hepatoblastoma PHiTT protocol CCLG Treatment guidelines for hepatoblastoma IV infusion PHiTT protocol As per SIOPEL 5 IV infusion /oral Oral thalidomide PHiTT protocol IV infusion / IV bolus, Oral sorafenib PO Oral thalidomide Oral Sorafenib LCH IV Iv bolus /oral Iv vinblastine CCLG Guidelines for LCH 2010 – currently being updated As per LCH-S 2005 Iv infusion / iv bolus / Iv vinblastine oral Oral MP /MTX Oral 6MP / MTX Oral MP /MTX 7 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Initial treatment Neuroblastoma Initial therapy: Stage IV / High risk Intermediate and low risk Neuroblastoma Relapse / second line therapy Regimen / protocol CCLG guidelines for nasopharyngeal carcinoma 2013 Routes administration Iv infusion of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG IM Interferon IM interferon HR-NBL-1-SIOPEN CCLG guidelines for High Risk Neuroblastoma (Mar 2019) As per CCLG guidelines for low and intermediate risk neuroblastoma Feb 2020 CCLG guidelines for relapsed and refractory neuroblastoma Iv infusion, iv bolus, oral, s/c Iv bolus / infusion Iv infusion Oral cis-retinoic acid Oral cis-retinoic acid As per BEACON trial Irinotecan + temozolomide Iv infusion / oral (as per CCLG guidelines) Cyclophosphamide and topotecan as per CCLG guidelines Topotecan + temozolomide (as per CCLG guidelines) Oral etoposide (as per CCLG guidelines) Iv infusion / oral oral Oral temozolomide Oral temozolomide IV Irinotecan (Level 2 only) Oral temozolomide Oral etoposide Oral temozolomide Oral etoposide 8 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Oral temozolomide (as per oral Oral temozolomide CCLG guidelines) Dinituximab beta as per NICE guidance Topotecan,Vincristine and IV Infusion / IV bolus Doxorubicin as per CCLG Guideline HD-ICE, MD-ICE or LD-ICE as per CCLG guideline Hu3F8 as per YmAbs study IV infusion s/c GMCSF IV hu3F8 GM-CSF Non-rhabdomyosarcoma soft tissue EpSSG NRSTS 2005 IV bolus, iv infusion sarcoma protocol (STS 2006 03) Iv vincristine Iv actinomycin Osteosarcoma: Initial therapy Relapse / rescue therapy: Pancreatoblastoma CCLG flowsheet Oct 2019 Iv infusion Mifamurtide as per NICE Iv infusion TA Ifosamide /etoposide High dose MTX Gemcitabine/ Docetaxel Iv infusion Iv infusion IV infusion CCLG guidelines (2003) Iv infusion Iv mifamurtide Retinoblastoma 9 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Initial therapy Initial therapy enucleation after unilateral CCLG guidelines (2008) CCLG Guideline for management of children with intraocular retinoblastoma II Second line chemo Jan 2008 CCLG Guidelines for the management of children with advanced unilateral retinoblastoma following primary enucleation May 2018 IV bolus / infusion IV bolus / infusion IV bolus / IV infusion Rhabdomyosarcoma Initial therapy (localised) Initial therapy (metastatic) As per RMS 2005 As per guidelines within RMS 2005 and CCLG guidelines (Nov 2013) Iv bolus / iv infusion / oral Iv bolus / iv infusion IV vincristine IV actinomycin Iv vinorelbine Oral cyclophosphamide IV vincristine Oral cyclophosphamide Relapsed disease EpSSG Phase II committee IV bolus/ IV infusion Relapsed RMS and CCLG guidelines (Aug 2013) 10 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication Wilms’ tumour / Clear Cell Sarcoma Kidney Regimen / protocol CCLG Renal tumour clinical management guidelines Jan 2020 Routes administration Iv bolus/infusion of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Iv vincristine / actinomycin Iv doxorubicin (level 2) IV irinotecan (level 2) Relapsed disease TVD As per UK W-R Iv infusion IV infusion / iv bolus Iv vincrisitne actinomycin Iv doxorubicin (level 2) CNS TUMOURS Low grade glioma First line therapy Second line therapies: As per Low grade glioma 2 IV bolus, iv infusion protocol Weekly vinblastine IV bolus Vinilo trial IV bolus and oral Weekly vinblastine IV bolus IV vincristine, IV carboplatin (level 2 only) Iv vinblastine (PTC only) IV vinblastine Oral Nilotinib High grade glioma CCLG guidelines Oral Oral temozolomide Oral temozolomide Infant high grade glioma European study guidelines 11 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication DIPG Regimen / protocol BIOMEDE trial Routes administration Oral of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG Oral dasatinib, oral everolimus, oral erlotinib Medulloblastoma Standard risk High risk Infants (≤ 3 years) Relapse / refractory CCLG guidelines (Jan 2019) CCLG guidelines (Jan 2015) CCLG interim guidelines March 2019 Oral etoposide then consideration of autograft IV bolus / infusion / oral IV infusion / bolus / oral IV infusion / bolus IV infusion / oral IV vincristine Oral lomustine IV vincristine Oral etoposide Oral lomustine Oral etoposide Ependymoma Standard risk CCLG Interim guidelines for recurrent Medulloblastoma Dec 2018 CCLG guidelines IV infusion Infants Ependymoma II trial IV bolus / IV infusion UKCCSG Baby Brain IV infusion / bolus protocol (CNS 2007 09) CCLG Infant medulloblastoma – interim guidance Jan 2019 Headstart II SIOP Ependymoma II trial IV infusion / bolus and PO Oral valproate 12 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 Disease / Indication ATRT CPC Germ cells tumours Pinealoblastoma > 3 yrs of age Regimen / protocol Routes administration of Drugs that can be Drugs that can to be Approved by given in POSCU given in Community SPCG EURHAB protocol Iv infusion / bolus / intraventricular CCLG guidelines ( May 2011) As per SIOP CPT 2009 IV infusion / IV bolus / study Intraventricular As per GCT II study IV infusion CCLG guidelines (Sept 2013) EMERGENCY REGIMENS EMPIRICAL High count leukaemia Spinal cord compression Iv daunorubicin +/- vinc +/- Iv infusion / bolus steroid Carbo / etoposide Iv infusion Other soft tissue mass requiring urgent treatment Susoected Burkitt’s lymphoma Vincristine/Dactinomycin/ Cyclophosphamide IV cyclophosphamide, vincristine and oral prednisolone IV bolus/ IV Infusion IV infusion. Bolus and oral PALLIATIVE Oral etoposide Oral Oral etoposide 13 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020 14 SOUTHAMPTON PAEDIATRIC ONCOLOGY AND HAEMATOLOGY PRINCIPAL TREATMENT CENTRE List of approved chemotherapy regimens – VERSION 2.0 9th June 2020
Url
/Media/UHS-website-2019/Docs/PaediatricOncology/Southampton-PTC-Approved-chemotherapy-regimens-9-June-2020.pdf

Welcome to Woodland ward special care baby unit - patient information

Description
This leaflet explains what facilities are available to you and your family and what you can expect during your baby's stay on Woodland ward special care baby unit.
Url
/Media/UHS-website-2019/Patientinformation/Neonatal/Welcome-to-Woodland-ward-special-care-baby-unit-3851-PIL.pdf

Your non-invasive ventilation (NIV) device: A40 Pro - patient information

Description
This factsheet explains how to use and care for your A40 Pro non-invasive ventilation (NIV) device safely at home.
Url
/Media/UHS-website-2019/Patientinformation/Respiratory/Your-non-invasive-ventilation-NIV-device-A40-Pro-3631-PIL.pdf

Your non-invasive ventilation (NIV) device: Lumis 150 - patient information

Description
This factsheet explains how to use and care for your Lumis 150 non-invasive ventilation (NIV) device safely at home.
Url
/Media/UHS-website-2019/Patientinformation/Respiratory/Your-non-invasive-ventilation-NIV-device-Lumis-150-3630-PIL.pdf

Your non-invasive ventilation (NIV) device: Trilogy Evo - patient information

Description
This factsheet explains how to use and care for your Trilogy Evo non-invasive ventilation (NIV) device safely at home.
Url
/Media/UHS-website-2019/Patientinformation/Respiratory/Your-non-invasive-ventilation-NIV-device-Trilogy-Evo-3629-PIL.pdf

Your non-invasive ventilation (NIV) device: VIVO 55 - patient information

Description
This factsheet explains how to use and care for your VIVO 55 non-invasive ventilation (NIV) device safely at home.
Url
/Media/UHS-website-2019/Patientinformation/Respiratory/Your-non-invasive-ventilation-NIV-device-VIVO-55-3628-PIL.pdf
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