Clark, Dr Tristan

BM, MRCP, MD, DTM&HDr Tristan Clark


Infectious diseases and general internal medicine


Respiratory viruses

Training and education

  • Bachelor of Medicine, University of Southampton medical school, 1998
  • Diploma in Tropical Medicine and Hygiene, Liverpool School of Tropical Medicine, 2000
  • Membership of the Royal College of Physicians, London, 2002
  • MD, University of Leicester, 2013.


Dr Clark joined the Trust as a consultant in infectious diseases in October 2013, and as a senior lecturer in infectious diseases at the University of Southampton.

He trained in infectious diseases and general internal medicine in Leicester as well as spending periods of time working and training in London (Hospital for Tropical Diseases), Australia (Darwin) and Africa (Sudan).

Dr Clark spends half of his time performing clinical duties including the inpatient management of patients with complex infection, and infectious diseases outpatient clinics. He is also responsible for the clinical supervision of infectious diseases trainees.

Within the specialty of infectious diseases Dr Clark has an interest and expertise in

  • respiratory virus infection (including seasonal and pandemic influenza)
  • HIV infection
  • tuberculosis (including multi-drug resistant TB)
  • chronic viral hepatitis (B and C)
  • pyrexia of unknown origin
  • imported infection (including malaria)
  • travel medicine and global health.

Key achievements

  • Performing and publishing the first human vaccine trial against H1N1 pandemic influenza in 2009 (New England Journal of Medicine, 2009 – see details below). 
  • Successfully running and developing a field hospital in Bentiu, Unity State, Sudan whilst working for the international aid agency Medecins Sans Frontieres (MSF) in 2003 to 2004.
  • Developing infectious diseases services.


Dr Clark spends half of his time performing research at the University of Southampton. His research interests include

  • pandemic influenza vaccine trials
  • respiratory virus infection in hospitalised adults
  • point of care diagnostics.

Selected publications

  • Bafadhel M*, Clark TW*, Reid C, Medina MJ, Batham S, Barer MR, Nicholson KG, Brightling CE.Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD. Chest. 2011 Jun;139(6):1410-8. *Joint first authors.
  • Nicholson KG, Abrams KR, Batham S, Clark TW, Hoschler K, Lim WS, Medina MJ, Nguyen-Van-Tam JS, Read RC, Warren FC, Zambon M. Immunogenicity and safety of a two-dose schedule of whole-virion and AS03A-adjuvanted 2009 influenza A (H1N1) vaccines: a randomised, multicentre, age-stratified, head-to-head trial. Lancet Infect Dis. 2011 Feb;11(2):91-101.
  • Clark TW, Daneshvar C, Pareek M, Perera N, Stephenson I. Enteric fever in a UK regional infectious diseases unit: a 10 year retrospective review. J Infect. 2010 Feb;60(2):91-8. doi: 10.1016/j.jinf.2009.11.009.
  • Clark TW, Pareek M, Hoschler K, Dillon H, Nicholson KG, Groth N, Stephenson I.Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine. N Engl J Med. 2009 Dec 17;361(25):2424-35.

More information on Dr Clark's research and publications is available on the University of Southampton website.


Contact Dr Clark via Diana Castle on 023 8120 4271 or email