Southampton is monitoring large numbers of people long-term to better understand the origins and influences of chronic musculoskeletal diseases like rheumatoid arthritis, osteoporosis and conducting research into better ways of managing and treating these conditions.
Building on the decades-long, detailed work with Southampton women and families over multiple generations conducted by our MRC Lifecourse Epidemiology Unit, our researchers are pursuing key activities including:
- Delineating the environmental influences throughout the lifecourse of chronic musculoskeletal diseases (osteoporosis, osteoarthritis, sarcopenia, inflammatory rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and lupus), and developing population-based and high-risk preventive strategies against these disorders
- Maintaining and developing long-term cohort studies assembled in Southampton as national and international resources to explore the mechanisms underlying the developmental origins of musculoskeletal health and disease
- Linking genetic, epigenetic, metabolomic and proteomic techniques to understand developmental influences on musculoskeletal disease susceptibility, and their transmission across generations.
- Study of musculoskeletal health literacy approach to encourage young people to start to engage in understanding their musculoskeletal health.
- Hosting the Arthritis Research-UK/MRC Centre for Musculoskeletal Health and Work.