Slaght, Dr Seán J.

BSc (Hons), PhD, MB, BCh, FRCP (London)Slaght, Dr Sean (neurology) photo

Specialty

Neurology

Sub-specialty

Epilepsy

Training and education

  • BSc (Hons) - Cardiff University, 1999
  • PhD - Cardiff University, 2002
  • MB BCh (bachelor of medicine, bachelor of surgery) - University of Wales, 2004
  • Junior doctor training - Cardiff and London - 2004 to 2008
  • Specialist neurology training - Southampton, 2008 to 2012
  • Fellowship in complex epilepsy - King's College Hospital, London, 2012 to 2013

Experience

Dr Slaght joined the Trust as a consultant neurologist in 2014. He also worked here between 2008 and 2012 as a registrar.

As well as providing general neurology and specialist epilepsy services to outpatients in Portsmouth, Dr Slaght runs a specialist epilepsy clinic here at Southampton General Hospital. He is also the clinical lead for neurology.

Dr Slaght is interested in all areas of general and acute neurology (neurological conditions that require urgent care). His subspecialty interest is complex epilepsy, including the preparation for epilepsy surgery. He is also part of the Sleep MDT at Queen Alexandra Hospital in Portsmouth.

Research

For his PhD, Dr Slaght studied the cellular mechanism of absence seizures (seizures in the form of a sudden loss of awareness). He is the principal investigator for many clinical trials studying epilepsy and non-epileptic attack disorder, a non-epilepsy related condition that causes patients to have seizures.

Dr Slaght has published the following articles:

  • Crisp SJ, Dixon CL, Jacobson L, Chabrol E, Irani SR, Leite MI, Leschziner G, Slaght SJ, Vincent A, Kullmann DM. Glycine receptor autoantibodies disrupt inhibitory neurotransmission. Brain. 2019 Nov 1;142(11):3398-3410.
  • Stavropoulos I, Louden W, Queally C, Adcock J, Tristram M, Neale M, Moran N,Flores L L, Nashef L, Richardson MP, Bell C, Slaght S, Aram J, Rayner N, PowellR, Mead A, Sen A, Elwes R. Perampanel for the treatment of epilepsy; Longitudinal actuarial analysis and dose responses based on monthly outcomes. Seizure. 2019 Jul;69:125-132.
  • Slaght SJ, Nashef L. An audit of external trigeminal nerve stimulation (eTNS) in epilepsy. Seizure. 2017 Nov;52:60-62.
  • Slaght SJ, Weir NU, Lovett JK. The workload of stroke thrombolysis: a prospective study in a district general hospital setting. Acute Med. 2011;10(1):10-2.
  • Mahon S, Vautrelle N, Pezard L, Slaght SJ, Deniau JM, Chouvet G, Charpier S. Distinct patterns of striatal medium spiny neuron activity during the natural sleep-wake cycle. J Neurosci. 2006 Nov 29;26(48):12587-95.  
  • Slaght SJ, Paz T, Chavez M, Deniau JM, Mahon S, Charpier S. On the activity of the corticostriatal networks during spike-and-wave discharges in a genetic model of absence epilepsy. J Neurosci. 2004 Jul 28;24(30):6816-25.
  • Slaght SJ, Paz T, Mahon S, Maurice N, Charpier S, Deniau JM. Functional organization of the circuits connecting the cerebral cortex and the basal ganglia: implications for the role of the basal ganglia in epilepsy. Epileptic Disord. 2002 Dec;4 Suppl 3:S9-22.  
  • Slaght SJ, Leresche N, Deniau JM, Crunelli V, Charpier S. Activity of thalamic reticular neurons during spontaneous genetically determined spike and wave discharges. J Neurosci. 2002 Mar 15;22(6):2323-34.

Dr Slaght was a collaborator on the following clinical trials:

  • Marson A et al. The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet. 2021;397(10282):1375-1386.

  • Marson A et al. The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial. Lancet. 2021;397(10282):1363-1374.

  • Goldstein LH et al. Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial. Lancet Psychiatry. 2020 Jun;7(6):491-505.

  • Goldstein LH, et al. Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort. Psychol Med. 2020 May 11:1-13.

  • Goldstein LH, et al. Characteristics of 698 patients with dissociative seizures: A UK multicenter

    study. Epilepsia. 2019 Nov;60(11):2182-2193.

Contact

If you're a patient in Southampton, you can contact Dr Slaght via his secretary Mary Hayes - call 023 8120 5771 or send an email.

Portsmouth patients can contact his secretary Caroline Stock at Queen Alexandra Hospital on 023 9228 6000 (ext. 6807) or email caroline.stock@porthosp.nhs.uk. Portsmouth Sleep clinic patients should use the patient enquiry form on the PHU website: https://www.porthosp.nhs.uk/departments/SleepPatientEnquiryForm.htm.