Lotery, Professor Andrew

Andrew LoteryMD, FRCOphth




Medical retina and inherited retinal diseases

Training and education

  • Medicine - Queen's University Belfast
  • MD, molecular genetics - Queen's University Belfast
  • Fellowship in molecular ophthalmology - University of Iowa
  • Assistant professor - University of Iowa


Prof Lotery joined the Trust in September 2002. Previously, he worked for four years at the University of Iowa Hospitals and Clinics. 

He specialises in looking after patients with inherited retinal diseases, diabetic retinopathy and age related macular degeneration - these conditions are also his main clinical interests. He also teaches and performs cataract surgery. He's a senior investigator for the National Institute for Health Research and chairman of the Royal College of Ophthalmologists’ scientific committee.

Key achievements

  • Establishing the vision research group at the University of Southampton
  • Developing anti-VEGF treatment (treatment that prevents the growth of new blood vessels in affected eyes) and photodynamic therapy for age-related macular degeneration at University Hospital Southampton
  • Establishing an ophthalmology clinical trials group at University Hospital Southampton

Awards and prizes

  • Nettleship medal of the Royal College of Ophthalmologists
  • Innovation award - University Hospital Southampton NHS Foundation Trust
  • Featured on list of Britain's top doctors in The Times
  • Clinical impact through research award - University Hospital Southampton


Prof Lotery's research interests include investigating the molecular basis of ophthalmic diseases such as macular degeneration, a condition he develops treatments for by conducting clinical trials. He also leads a research team which studies the genetics of eye diseases, and is working to develop new therapies for eye diseases with stem cells and retinal cell transplantation.

This research would not be possible without the financial support of the Gift of Sight appeal.

Find out more about Professor Lotery's vision research at the University of Southampton.

Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, Jones S, Collins A, Stone E, Lotery A. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. Lancet 2008;372:1828-34.

Goverdhan SV , Khakoo SI , Gaston H, Chen X, Lotery AJ . Age-related macular degeneration is associated with the HLA - Cw *0701 Genotype and the natural killer cell receptor AA haplotype. Invest Ophthalmol Vis.Sci. 2008;49:5077-82.

Goverdhan SV , Ennis S, Hannan SR , Madhusudhana KC, Cree AJ , Luff AJ , Lotery AJ . Interleukin-8 promoter polymorphism - 251A /T is a risk factor for age-related macular degeneration. Br J Ophthalmol 2008;92:537-40.

Goverdhan SV , Hannan S, Newsom RB , Luff AJ , Griffiths H, Lotery AJ . An analysis of the CFH Y402H genotype in AMD patients and controls from the UK, and response to PDT treatment. Eye 2008;22:849-54.

Raftery J, Clegg A, Jones J, Tan SC, Lotery A. Ranibizumab ( Lucentis ) versus bevacizumab ( Avastin ): modelling cost effectiveness. Br J Ophthalmol 2007;91:1244-6.

Raftery JP , Lotery A. The cheaper drug, bevacizumab , should be referred to NICE. BMJ 2007;334:381-2.

Ennis S, Goverdhan S, Cree A, Hoh J, Collins A, Lotery A. Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region. Br J Ophthalmol 2007;91:966-70.

Lotery AJ , Baas D, Ridley C, Jones RP , Klaver CC, Stone E, Nakamura T, Luff A, Griffiths H, Wang T, Bergen AA, Trump D. Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa . Hum. Mutat . 2006;27:568-74.

Goverdhan SV , Howell MW , Mullins RF , Osmond C, Hodgkins PR, Self J, Avery K, Lotery AJ . Association of HLA class I and class II polymorphisms with age-related macular degeneration. Invest Ophthalmol Vis.Sci. 2005;46:1726-34.

Stone EM, Braun TA, Russell SR , Kuehn MH , Lotery AJ , Moore PA, Eastman CG , Casavant TL , Sheffield VC. Missense variations in the fibulin 5 gene and age-related macular degeneration. N. Engl .J Med. 2004;351:346-53.

Lotery AJ , Jacobson SG , Fishman GA, Weleber RG , Fulton AB , Namperumalsamy P, Heon E, Levin AV , Grover S, Rosenow JR, Kopp KK , Sheffield VC, Stone EM. Mutations in the CRB1 gene cause Leber congenital amaurosis. Arch. Ophthalmol 2001;119:415-20.

Stone EM, Lotery AJ , Munier FL, Heon E, Piguet B, Guymer RH, Vandenburgh K, Cousin P, Nishimura D, Swiderski RE, Silvestri G, Mackey DA, Hageman GS , Bird AC, Sheffield VC, Schorderet DF . A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat .Genet. 1999;22:199-202.

Stone EM, Webster AR, Vandenburgh K, Streb LM , Hockey RR, Lotery AJ , Sheffield VC. Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration. Nat .Genet. 1998;20:328-9.

Lotery AJ , Ennis KT , Silvestri G, Nicholl S, McGibbon D, Collins AD, Hughes AE . Localisation of a gene for central areolar choroidal dystrophy to chromosome 17p . Hum. Mol .Genet. 1996;5:705-8.


You can contact Prof Lotery via his secretaries, Rowena Beckwith (Monday and Thursday) and Holly Bucci (Tuesday and Wednesday) - call 023 8120 4590 or 023 8120 5739.

Alternatively, click the links to email Rowena or Holly.