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Nicoll, Professor James AR

BSc MBChB MD FRCPath 

Specialty

Neuropathology 

Training and education

University of Bristol 

Experience

Professor Nicoll has worked for the Trust since September 2001.

I share responsibility for providing the clinical diagnostic neuropathology service to the Wessex Region (a population of approximately 3 million). I am involved in associated undergraduate and postgraduate teaching and training and I undertake research in Clinical Neurosciences. I am a member of the Royal College of Pathologists and the British Neuropathological Society. I participate in the Royal College of Pathologists Continuing Professional Development Scheme and the UK Neuropathology External Quality Assurance Scheme. I also have experience in medico-legal aspects of neuropathology.

I recently co-authored an introductory textbook on Neuropathology: Adams & Graham’s Introduction to Neuropathology. 3rd Edition.Graham DI, Nicoll JAR & Bone I.Published by Hodder Arnold, London, 2006. ISBN 0 340 81197 9.

My major research interests are in fields of brain injury, neurodegeneration and the potential for neuroregeneration. I am particularly interested in the underlying mechanisms and how genetic variation influences disease processes in the brain. 

Key achievements

  • Royal College of Pathologists Chair of Examiners for Neuropathology (2003/2004).
  • Royal College of Pathologists Examiner in Neuropathology (2001 on).
  • DEFRA/DoH Spongiform Encephalopathy Advisory Committee member (2005 on).
  • Medical Research Council Neurosciences and Mental Health Board (2004-2008).

     

Research

 i) Aß immunization in Alzheimer's disease can result in removal of plaques, but this does not seem to be sufficient to halt the neurodegeneration.

Nicoll et al, Nature Medicine,2003, 9,448-52
Nicoll et al. JNEN, 2006,65, 1040-8
Holmes et al, Lancet, 2008, 372, 216-32

ii) Identification of a genetically determined influence on outcome after traumatic brain injury based on variation of the APOE gene.

Nicoll et al, Nature Medicine, 1995, 1, 135-37
Teasdale et al, Lancet, 1997, 350, 1069-71
Teasdale et al. Brain, 2005, 128, 2556-61
Millar et al. JNNP, 2003, 74, 1047-52)
Horsburgh et al, Journal of Cerebral Blood Flow and Metabolism, 2000, 20, 458-62

iii) Identification of a genetically determined susceptibility to a specific sub-type of stroke (cerebral amyloid angiopathy-related haemorrhage) based on variation of the APOE gene

Nicoll et al, Annals of Neurology, 1997, 41, 716-21

iv) Association of interleukin-1 gene polymorphisms with Alzheimer's disease

Nicoll et al, Annals of Neurology, 2000, 47, 365-8

For further details please see my University of Southampton webpage.