Nicoll, Professor James AR




Training and education

University of Bristol 


Professor Nicoll has worked for the Trust since September 2001.

I share responsibility for providing the clinical diagnostic neuropathology service to the Wessex Region (a population of approximately 3 million). I am involved in associated undergraduate and postgraduate teaching and training and I undertake research in Clinical Neurosciences. I am a member of the Royal College of Pathologists and the British Neuropathological Society. I participate in the Royal College of Pathologists Continuing Professional Development Scheme and the UK Neuropathology External Quality Assurance Scheme. I also have experience in medico-legal aspects of neuropathology.

I recently co-authored an introductory textbook on Neuropathology: Adams & Graham’s Introduction to Neuropathology. 3rd Edition.Graham DI, Nicoll JAR & Bone I.Published by Hodder Arnold, London, 2006. ISBN 0 340 81197 9.

My major research interests are in fields of brain injury, neurodegeneration and the potential for neuroregeneration. I am particularly interested in the underlying mechanisms and how genetic variation influences disease processes in the brain. 

Key achievements

  • Royal College of Pathologists Chair of Examiners for Neuropathology (2003/2004).
  • Royal College of Pathologists Examiner in Neuropathology (2001 on).
  • DEFRA/DoH Spongiform Encephalopathy Advisory Committee member (2005 on).
  • Medical Research Council Neurosciences and Mental Health Board (2004-2008).



 i) Aß immunization in Alzheimer's disease can result in removal of plaques, but this does not seem to be sufficient to halt the neurodegeneration.

Nicoll et al, Nature Medicine,2003, 9,448-52
Nicoll et al. JNEN, 2006,65, 1040-8
Holmes et al, Lancet, 2008, 372, 216-32

ii) Identification of a genetically determined influence on outcome after traumatic brain injury based on variation of the APOE gene.

Nicoll et al, Nature Medicine, 1995, 1, 135-37
Teasdale et al, Lancet, 1997, 350, 1069-71
Teasdale et al. Brain, 2005, 128, 2556-61
Millar et al. JNNP, 2003, 74, 1047-52)
Horsburgh et al, Journal of Cerebral Blood Flow and Metabolism, 2000, 20, 458-62

iii) Identification of a genetically determined susceptibility to a specific sub-type of stroke (cerebral amyloid angiopathy-related haemorrhage) based on variation of the APOE gene

Nicoll et al, Annals of Neurology, 1997, 41, 716-21

iv) Association of interleukin-1 gene polymorphisms with Alzheimer's disease

Nicoll et al, Annals of Neurology, 2000, 47, 365-8

For further details please see my University of Southampton webpage.