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Herbertson, Dr Mike

BA FRCP FRCA

Specialty

Anaesthesia and critical care

Sub-specialty

Adult and paediatric cardiac anaesthesia
Adult cardiac critical care
Adult and paediatric spinal anaesthesia

Training and education

Medical school at Oxford University and The London Hospital, 1976 to 1982
General medicine, UK, 1982 to 1986
Anaesthesia and critical care, UK, 1986 to 1990
Adult and paediatric critical care, Canada, 1990 to 1993
Paediatric anaesthesia and critical care, USA, 1993 to 1994
Cardiac anaesthesia, UK, 1995 to 1997

Experience

Dr Herbertson has worked for University Hospital Southampton NHS Foundation Trust since July 1997. He has over 20 years' experience in anaesthesia and critical care.

Key achievements

Clinical lead for cardiac anaesthesia and cardiac critical care, 2005 to 2008.
Clinical lead for cardiac anaesthesia, 2008 to present.

Research

Gill RS, Herbertson MJ. Recombinant factor VIIa: a universal haemostatic? Editorial: Annals of Cardiac Anesthesia 2006; 9: 97-99.
Diprose P, Herbertson MJ, O’Shaughnessy D, Gill R. Activated recombinant factor VII after cardiopulmonary bypass reduces allogeneic transfusion in complex non-coronary cardiac surgery: randomized double-blind placebo-controlled pilot study. Br J Anaesth. 2005 Nov; 95(5):596-602. Epub 2005 Sep 23.
Diprose P, Herbertson MJ, O’Shaughnessy D, Deakin CD, Gill R. Reducing allogeneic transfusion in cardiac surgery – a randomised double blind placebo controlled trial of anti-fibrinolytic therapies used in addition to intra-operative cell salvage. Br J Anaesth. 2005 Mar; 94(3):271-8. Epub 2004 Dec 10.
McGill N, O’Shaugnessy D, Pickering R, Herbertson MJ, Gill RS. Mechanical Methods of reducing blood transfusion In Cardiac Surgery: randomised controlled trial. BMJ. 2002 Jun 1;324(7349):1299
Handel J, Wensley DF, Miller C, Herbertson MJ, Walley KR. Evaluation of the effects of nitric oxide on lung mechanics associated with pulmonary hypertension caused by endotoxemia in a porcine model. Canadian Journal of Anaesthesia.
Herbertson MJ, Werner HA, Walley KR. Inhibition of platelet activating factor ameliorates the decrease in myocardial contractility but does not improve hemodynamics during porcine endotoxemia. Crit Care Med.
Herbertson MJ, Werner HA, Studer W, Russell JA, Walley KR. Myocardial oxygen consumption is increased during inotropic therapy in sepsis and may account for much of the increase in whole body oxygen consumption.
Herbertson MJ, Werner HA, Struder W. Russell JA, Walley KR. Decreased left ventricular contractility during porcine endotoxemia is not prevented by ibuprofen. Crit Care Med 1996, 24(5): 815-819.
Herbertson MJ, Werner, HA, Walley KR. Nitric oxide synthase inhibition partially prevents decreased LV contractility during endotoxemia. Am J Physiol 1996, 270(6 Pt 2): 1979-1984.
Herbertson MJ, Werner HA, Goddard DM, Russell JA, Wheeler A, Coxon R, Walley KR. Anti-tumour necrosis factor  prevents decrease in ventricular contractility in endotoxemic pigs. Am J Respir Crit Care Med 1995, 152: 480-488.
Herbertson MJ, Werner HA, Iversen K, Walley, KR. Myocardial oxygen extraction ration is decreased during endotoxemia in pigs. J Appl Physiol 1995, 79(2): 479–486.
Werner HA, Herbertson MJ, Walley KR. Amrinone increases left ventricular contractility and diastolic compliance in endotoxemia. Am J Respir Crit Care Med 1995, 152: 496-503.
Herbertson MJ, Handel J. Stridor in the small infant. Br J. Hosp Med 1995, 54(8): 418.
Werner HA, Herbertson MJ, Seear MD. Function characteristics of pediatric venovenous hemofiltration. Crit Care Med 1994, 22(2): 320-325.
Werner HA, Herbertson MJ, Sear MD. Operating characteristics of pediatric continuous arteriovenous hemofiltration in an animal model. Pediatric Nephrol 1993, 7(2): 189-193.
Cooper DJ, Herbertson MJ, Werner HA, Walley KR. Bicarbonate does not increase left ventricular contractility during L-Lactic acidemia in pigs. Am Rev Resp Dis 1993, 148: 317-322.
Herbertson MJ, Russell JA. Trends in Drug Therapy: Noncardiogenic pulmonary edema. Drug Therapy 1993.
Herbertson MJ, Cunningham K, Russell JA. The Adult Respiratory Distress Syndrome. Curr Opin Anaestheiol 1992, 5: 218–224

Abstracts published

NA McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. Autologous predonation of red blood cells immediately before coronary artery bypass surgery does not reduce transfusion requirements. Anesthesia and Analgesia 2001:92; 4S; SCA7.
TR Betts, NA McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. Acute Normovolemic hemodilution does not result in an increased number of ischemic events during coronary artery bypass grafting. Anesthesia and Analgesia 2001:92; 4S; SCA16.
TR Betts, NA McGill, D O’Shaughnessy, MJ Herbertson, RS Gill.Is there a gold standard for diagnostic peri operative myocardial infarction during coronary artery bypass grafting. Anesthesia and Analgesia 2001:92; 4S; SCA150.
NA McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. Myocardial protection during coronary artery bypass grafting is similar using ventricular fibrillation or cardioplegia with cold crystalloid or cold blood solution. Anesthesia and Analgesia 2001:92; 4S; SCA127.
N A McGill, D O’Shaughnessy, M Herbertson, R Gill. Acute Normovolemic Hemodilution is Safe in Patients with known Coronary Disease Anesthesia and Analgesia 2001:92; 4S S60.
A McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. Thromboelastography: the effect of cardiopulmonary bypass and cell salvage. Anesthesia and Analgesia 2001:92; 4S; S61.
Herbertson MJ, Werner HA, Walley KR. Platelet activating factor antagonism improves cardiovascular function during endotoxemia. Am J Resp & Crit Care Med 1995, 151(Apr): A447.
Herbertson MJ, Werner HA, Handel J, Walley KR. L-Nitro arginine partially reverses decreased myocardial contractility in endotoxemia. Am J Resp & Crit Care Med 1995, 151(Apr): A15.
Goddard CM, Allard MF, Hogg JC, Herbertson MJ, Walley KR. Myocardial leukocyte transit time is increased after endotoxin infusion in pigs. Am J Resp & Crit Care Med 1995, 151(Apr): A316.
Werner HA, Nasseri B, Herbertson MJ, Lange PE. Diafiltration increases solute clearance of small pediatric filters. Am J Resp & Crit Care Med 1995, 151(Apr): A744.
Miller CC, Herbertson MJ, Walley KR. Effects of inhaled nitric oxide on early and late phase endotoxin-induced pulmonary hypertension in pigs. Am J Resp & Crit Care Med 1994, 149(Apr): A442.
Herbertson MJ, Werner HA, Graham RE, Rangno RE, Walley KR. Endogenous catecholamines may delay the decrease in myocardial contractility during endotoxemia. Crit Care Med 1993, 21(4): S134.
Herbertson MJ, Werner HA, Goddard CM, Russell JA, Walley. Anti-tumour necrosis factor decreases the hemodynamic disturbance in endotoxemia. FASEB 1993, 7(3): A322.
Herbertson MJ, Werner HA, Minshall DK, Iversen K, Walley KR. Myocardial blood flow is maintained but redistributed during endotoxemia. Am Rev Resp Dis 1993, 147(Apr): A611.
Herbertson MJ, Werner HA, Studer w, Russell JA, Walley KR. Ibuprofen does not prevent the decreased myocardial contractility in endotoxemia. Am Rev Resp Dis 1993, 147(Apr): A98.
Herbertson MJ, Werner HA, Studer W, Russell JA, Walley KR. Ibuprofen prevents the early but not the late hemodynamic changes during endotoxemia. Crit Care Med 1993, 21(4): S135.
Herbertson MJ, Werner HA, Studer W, Russell JA, Walley KR. Increased oxygen consumption, occurring secondary to inotropic treatment during sepsis, may principally be occurring in the myocardium. Anesthesiology 1993, 79(3A): A251.
Herbertson MJ, Werner HA, Goddard CM, Russell JA, Walley KR. Anti-tumour necrosis factor ameliorates the decrease in myocardial contractility in endotoxemia. Am Rev Resp Dis 1993, 147(Apr): A202.
Miller CC, Miller JWR, Herbertson MJ, Walley KR. Absorption of nitric oxide and production of nitrogen dioxide in the tracheotomized and ventilated pig. Am Rev Resp Dis 1993, 147(Apr): A893.
Werner HA, Herbertson MJ, Walley KR. Amrinone reverses the decrease of diastolic compliance in endotoxemia. Crit Care Med 1993, 21(4): S261.
Werner HA, Herbertson MJ, Walley KR. Amrinone increases contractility but dangerously reduces after load during endotoxemia. Am Rev Resp Dis 1993 147(Apr): A98.
Walley KR, Werner HA, Herbertson MJ. Decreased myocardial oxygen consumption during endotoxemia is accounted for by decreased myocardial work. FASEB 1993, 7(3): A321.
Werner HA, Herbertson MJ, Seear MD. Operating characteristics of hemofiltration in a small animal model. Chest 1993, 102(2): 71S.
Herbertson MJ, Werner HA, Iversen K, Walley KR. Decreased myocardial oxygen extraction and contractility in porcine endotoxemia. Am Rev Resp Dis 1992, 145(4): A74.

Presentations

Diprose P, Herbertson MJ, O'Shaughnessy D, Gill R. A Pilot Double Blind Randomised Placebo Controlled Trial of the Use of Recombinant Factor VIIa in High Transfusion Risk Cardiac Surgery. EACTA Conference. London. June 2004.
Diprose P, Dawkins S, Deakin CD, Gill R, Herbertson M, Smith DC. The effect of anti-fibrinolytic agents on exhaled nitric oxide during cardiac surgery: a double blind placebo controlled trial. EACTA. Prague. May 2003.
Diprose P, Royle E, O’Shaughnessy D, Gill R, Herbertson M. Targeted therapy of post-cardiopulmonary bypass bleeding using novel thromboelastograph® (TEG®) system reagents: a case report. EACTA. Prague. May 2003.
Diprose P, Royle E, O’Shaughnessy D, Gill R, Herbertson M. Targeted therapy of post-cardiopulmonary bypass bleeding using novel thromboelastograph® (TEG®) system reagents: a case report. EACTA. Prague. May 2003.
Diprose P, Dawkins S, Gill R, Herbertson M, Deakin CD. Anti-fibrinolytics and lung water in cardiac surgery – interim results of a prospective randomised double blind placebo controlled trial. SCA Conference. Miami. April 2003.
Diprose P, Herbertson M, O’Shaughnessy D, Gill R. Factor VIIa for severe cardiac surgical bleeding. SCA Conference. Miami. April 2003.
Gorf L, Diprose P, Deakin C, Herbertson M, Gill R. The effects of aprotinin and tranexamic acid on inflammatory mediators in cardiac surgery. ACTA Conference. Cambridge. June 2002.
Diprose P, Herbertson M, O’Shaughnessy D, Gill R. Factor VIIa for severe cardiac surgical bleeding. NATA Conference - Rome. April 2002.
Diprose P, Yates S, O’Shaughnessy D, Herbertson M, Gill R. Survey of provision of blood products for cardiac surgery in the UK. ACTA Conference – Cambridge. June 2001.
N McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. A Randomised Controlled Trial of Blood Conservation Technologies in Elective Coronary Artery Bypass Surgery ACTA Conference. Cambridge. June 2001.
J Nanson, NA McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. The effect of Aspirin. Therapy on the Thrombo-elastogram following Cardio Pulmonary Bypass. ACTA Conference. Blackpool. Nov 2000.
NA McGill, D O’Shaughnessy, MJ Herbertson, RS Gill. The effects of Intra-Operative Cell Salvage on the Thrombo-elastogram following Cardio Pulmonary Bypass ACTA Conference - Blackpool. Nov 2000.
N A McGill, D O’Shaughnessy, M Herbertson, R Gill. Acute Normovolemic Hemodilution is Safe in Patients with known Coronary Disease. ACTA Conference - Cambridge. June 2000.
Herbertson MJ, Fenwick J, Tweedale M. Extra-corporeal CO2 Removal. Canadian Society of Critical Care, Quebec City, Canada. September 1991.
Herbertson MJ, Wilkins R, Edwards D. The Management of a Patient with Pneumococcal Sepsis. The Royal Society of Medicine. London, UK. September 1987.

Book chapters and contributions

Herbertson MJ. Questions and Summaries contributed. Key Topics for Cardiac Surgical Examinations. Editors Langley S, Ohri S, In preparation.
Weidmann C, Herbertson MJ. Key Topics in Cardiac Surgery. Myocardial Metabolism. Ed Ohri SK, Tang A, Taylor, and Francis. Jan 2005 pp88-92.
Diprose P, Gill R & Herbertson M. Is recombinant factor VII a universal haemostatic? (Book Chapter). Yearbook of Intensive Care and Emergency Medicine 2003. Ed. Vincent JL pp 136-148.
Herbertson MJ. Questions and Summaries contributed. Q Based Anesthesia for Examinations. Editors: MacIndoe and Hammond. 1998
Herbertson MJ, Walley KR. ICU – The Team Approach. Book Chapter. Editors: Hall, Schmidt & Wood. The Pathophysiology of Critical Care Medicine. McGraw Hill 2nd Ed 1999.